Pregabalin augmentation to sertraline-risperidone combination in the treatment of obsessive-compulsive disorder.

Sir: Despite the marked progress in the pharmacologic treatment of obsessive-compulsive disorder (OCD)—especially with high doses of serotonin reuptake inhibitors (SRIs), alone or in combination with low doses of antipsychotics—a substantial proportion of patients fail to respond to it. In such cases, an augmentation tactic with drugs from other chemical classes, including antiepileptic drugs, seems advisable. We report on such a case, in which the adjunction of the newer antiepileptic drug pregabalin led to a patient’s marked improvement.